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New Study Finds Few Risks of Birth Defects from Antidepressant Use during Pregnancy

CDC, Jul 03, 2007

Use of certain antidepressants, selective serotonin-reuptake inhibitors most commonly known as SSRIs, during pregnancy does not significantly increase the risk for most birth defects, according to a new Centers for Disease Control and Prevention (CDC) study, released today in the New England Journal of Medicine (NEJM).

The study, “Use of Selective Serotonin-Reuptake Inhibitors in Pregnancy and the Risk of Birth Defects,” found no significant increase in the risks for the majority of birth defects assessed when all SSRIs were studied together. This finding includes the risk for congenital heart defects, which were associated with SSRI use in previous studies. Researchers, did, however, find associations between SSRI use and three specific birth defects: a defect of the brain, one type of abnormal skull development and a gastrointestinal abnormality. CDC plans to continue to study the association to clarify whether a true risk exists.

“Overall, our results are generally reassuring with respect to the use of antidepressants during pregnancy,” said Jennita Reefhuis, a CDC epidemiologist and one of the authors of the study. “We know that both the mother and baby benefit when a pregnant woman with a serious depressive illness is able to stay on some sort of treatment. The risks may vary for different SSRIs and groups of women. It's important that women talk with their doctor about the risks and benefits of taking SSRIs during pregnancy.”

The study examined data from 9,622 infants with major birth defects and 4,092 infants without major birth defects, all born during 1997–2002. The data were obtained from the CDC–funded National Birth Defects Prevention Study (NBDPS). The NBDPS is an ongoing study that collects information from the states of Arkansas, California, Georgia, Iowa, Massachusetts, New York, North Carolina, Texas and Utah on the pregnancies of mothers of children with and without birth defects. It is one of the largest epidemiological efforts ever undertaken in the United States to identify causes of birth defects.

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